N-Methyl-exo-THPO
N-Methyl-exo-THPO
MW:
168.19
logP:
0.81
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
IUPAC: 4-(methylamino)-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol
Synonyms:
N-Me-exo-THPO, N-Methyl-exo-THPO

Reference GATs GAT1 GAT2 GAT3 GAT4 Method Brain region Comment
White et al., 2002  405         Radioactive labelling cultured neurons 
White et al., 2002  48         Radioactive labelling cultured astrocytes 
White et al., 2002    450  >3000  >3000  >3000 Radioactive labelling  
Falch et al., 1999  63         Radioactive labelling synaptosome
Falch et al., 1999  423         Radioactive labelling cultured neurons
Falch et al., 1999  28         Radioactive labelling cultured astrocytes

GATs or EAATs means measurements on brain homogenates, slices, cultured neurons or astrocytes, i.e. not cloned transporters.

IC50 and Ki values are given in µM.

Ki values are indicated as italic.

Compounds affecting transport indirectly are shown in red.