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Guvacine
MW:
127.141
logP:
-0.34
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
5.02 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: Preincubation: 15 min.Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
Guvacine
MW:
127.141
logP:
-0.34
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
6.94 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: No preincubation.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
DABA
MW:
118.134
logP:
-3.826
H-acceptors:
4
H-donors:
3
Rotatable bonds:
3
GATs:
43.01 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: Preincubation: 15 min.Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
DABA
MW:
118.134
logP:
-3.826
H-acceptors:
4
H-donors:
3
Rotatable bonds:
3
GATs:
43.46 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: No preincubation.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
3-aminocyclohexane-1-carboxylic acid
MW:
143.184
logP:
0.444
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
8.46 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: Preincubation: 15 min.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
3-aminocyclohexane-1-carboxylic acid
MW:
143.184
logP:
0.444
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
29.03 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: No preincubation.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
Nipecotic acid
MW:
129.157
logP:
-0.013
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
4 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: Preincubation: 15 min.
Preparation: crude synaptosomal P2 fraction containing primarily mitochondria, synaptosomes and perhaps gliosomes.
Nipecotic acid
MW:
129.157
logP:
-0.013
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
5.78 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: No preincubation.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
(1r,4r)-2-aza-bicyclo(2.1.1)hexane-1,4-dicarboxylicacid
MW:
171.15
logP:
-0.84
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
 
EAAT1:
 
EAAT2:
45 µM
EAAT3:
 
EAAT4:
 
EAAT5:
 
(2S)-t-PDC
MW:
159.14
logP:
-1.1
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
 
EAAT1:
 
EAAT2:
8 µM
EAAT3:
 
EAAT4:
 
EAAT5: