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L-CCG-IV
MW:
159.14
logP:
-1.35
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
 
EAAT1:
 
EAAT2:
 
EAAT3:
100 µM
EAAT4:
 
EAAT5:
 
L-CCG-III
MW:
159.14
logP:
-1.35
H-acceptors:
5
H-donors:
3
Rotatable bonds:
3
EAATs:
 
EAAT1:
 
EAAT2:
 
EAAT3:
10 µM
EAAT4:
 
EAAT5:
 
L-CCGII
MW:
159.14
logP:
-1.35
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
 
EAAT1:
 
EAAT2:
 
EAAT3:
400 µM
EAAT4:
 
EAAT5:
 
L-CCG-I
MW:
159.14
logP:
-1.35
H-acceptors:
4
H-donors:
3
Rotatable bonds:
2
EAATs:
 
EAAT1:
 
EAAT2:
 
EAAT3:
900 µM
EAAT4:
 
EAAT5:
 
beta-Proline
MW:
115.06
logP:
-0.52
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
32.34 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: Preincubation: 15 min.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
beta-Proline
MW:
115.06
logP:
-0.52
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
49.82 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: No preincubation.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
homo-beta-proline
MW:
129.16
logP:
-0.41
H-acceptors:
3
H-donors:
2
Rotatable bonds:
2
GATs:
1.58 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: Preincubation: 15 min.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
homo-beta-proline
MW:
129.16
logP:
-0.41
H-acceptors:
3
H-donors:
2
Rotatable bonds:
2
GATs:
2 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: No preincubation.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
cis-4-OH-nipecotic acid
MW:
145.16
logP:
-1.23
H-acceptors:
3
H-donors:
3
Rotatable bonds:
1
GATs:
4.51 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: Preincubation: 15 min.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.
cis-4-OH-nipecotic acid
MW:
145.16
logP:
-1.23
H-acceptors:
3
H-donors:
3
Rotatable bonds:
1
GATs:
7.5 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
Brain region: diencephalon-midbrain
Method: Radioactive labelling
Substrate: n/a
Comment: No preincubation.
Preparation: crude synaptosomal P2 fraction containing primarily nitochondria, synaptosomes and perhaps gliosomes.