Falch et al., 1986
morpholine-6-carboxylic acid
MW:
131.13
logP:
-0.1
H-acceptors:
2
H-donors:
2
Rotatable bonds:
1
GATs:
300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
isoxazolidine-5-carboxylic acid
MW:
117.1
logP:
-0.52
H-acceptors:
2
H-donors:
2
Rotatable bonds:
1
GATs:
>300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(RS)-3-OCH3-GABA
MW:
133.15
logP:
-1.27
H-acceptors:
2
H-donors:
2
Rotatable bonds:
4
GATs:
>300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(S)-(+)-DHM
MW:
116.12
logP:
-0.68
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
>300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(R)-(-)-DHM
MW:
116.12
logP:
-0.68
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
70 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(S)-(+)-3-OH-GABA
MW:
119.12
logP:
-1.63
H-acceptors:
2
H-donors:
3
Rotatable bonds:
3
GATs:
29 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(R)-(-)-3-OH-GABA
MW:
119.12
logP:
-1.63
H-acceptors:
2
H-donors:
3
Rotatable bonds:
3
GATs:
67 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(RS)-3-OH-DAVA
MW:
133.15
logP:
-1.53
H-acceptors:
2
H-donors:
3
Rotatable bonds:
4
GATs:
>300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(RS)-2-OH-DAVA
MW:
133.15
logP:
-1.19
H-acceptors:
2
H-donors:
3
Rotatable bonds:
4
GATs:
>300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(RS)-2-OH-GABA
MW:
119.12
logP:
-1.64
H-acceptors:
2
H-donors:
3
Rotatable bonds:
3
GATs:
5 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
homomuscimol
MW:
128.13
logP:
-0.26
H-acceptors:
3
H-donors:
2
Rotatable bonds:
2
GATs:
>300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
muscimol
MW:
114.1
logP:
-0.37
H-acceptors:
3
H-donors:
2
Rotatable bonds:
1
GATs:
240 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
trans-5-amino-pent-2-enoic acid
MW:
115.13
logP:
-0.42
H-acceptors:
3
H-donors:
2
Rotatable bonds:
3
GATs:
96 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
trans-ACA
MW:
101.1
logP:
-0.7
H-acceptors:
3
H-donors:
2
Rotatable bonds:
2
GATs:
9.5 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
DAVA
MW:
117.15
logP:
-0.4
H-acceptors:
3
H-donors:
2
Rotatable bonds:
4
GATs:
55 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(S)-Baclofen
MW:
213.661
logP:
1.42
H-acceptors:
3
H-donors:
2
Rotatable bonds:
4
GATs:
>300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
(R)-Baclofen
MW:
213.661
logP:
1.42
H-acceptors:
3
H-donors:
2
Rotatable bonds:
4
GATs:
300 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4:
 
GABA
MW:
103.12
logP:
-0.594
H-acceptors:
3
H-donors:
2
Rotatable bonds:
3
GATs:
3 µM
GAT1:
 
GAT2:
 
GAT3:
 
GAT4: